Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
PRIMECAP Management Company 10,253,500 14.53 192,000 12/31/20
Federated Hermes Global Investment Management Corp. 7,442,600 10.55 -10,411 12/31/20
BlackRock Institutional Trust Company, N.A. 4,996,662 7.08 694,478 12/31/20
BVF Partners L.P. 4,361,238 6.18 -224,400 12/31/20
Adage Capital Management, L.P. 4,000,000 5.67 2,000,000 1/13/21
The Vanguard Group, Inc. 3,674,694 5.21 118,749 12/31/20
Delphi Ventures L.P. 2,426,702 3.44 -- 12/31/20
Wellington Management Company, LLP 2,418,916 3.43 305,144 12/31/20
Advanced Technology Ventures 2,110,082 2.99 -- 3/31/20
Great Point Partners, LLC 1,845,000 2.61 -1,073,581 12/31/20

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
PRIMECAP Odyssey Aggressive Growth Fund 7,047,900 9.61 -- 12/31/20
Federated Hermes Kaufmann Small Cap Fund 3,960,000 5.40 -- 12/31/20
Federated Hermes Kaufmann Fund 3,385,000 4.62 -- 12/31/20
Vanguard US Opportunities Fund 3,185,600 4.35 172,000 12/31/20
Vanguard Total Stock Market Index Fund 2,126,813 2.90 -- 3/31/21
iShares Russell 2000 ETF 1,655,503 2.26 30,245 3/31/21
Vanguard Extended Market Index Fund 926,583 1.26 -- 3/31/21
iShares NASDAQ Biotechnology ETF 592,579 0.81 -28,476 3/31/21
iShares Russell 2000 Growth ETF 585,522 0.80 -3,635 3/31/21
Fidelity Small Cap Index Fund 427,152 0.58 65,182 1/31/21

* Insider values reflect direct beneficial ownership.

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