Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
PRIMECAP Management Company 10,333,700 13.96 80,200 3/31/21
Federated Hermes Global Investment Management Corp. 6,667,800 9.00 -774,800 3/31/21
BlackRock Institutional Trust Company, N.A. 5,883,955 7.95 887,293 3/31/21
BVF Partners L.P. 5,566,690 7.52 1,205,452 3/31/21
Adage Capital Management, L.P. 4,000,000 5.40 -- 3/31/21
The Vanguard Group, Inc. 3,702,517 5.00 27,823 3/31/21
Delphi Ventures L.P. 2,426,702 3.28 -- 3/31/21
Advanced Technology Ventures 2,110,082 2.85 -- 3/31/21
Dimensional Fund Advisors, L.P. 1,433,120 1.94 -48,114 3/31/21
State Street Global Advisors (US) 1,204,561 1.63 -52,834 3/31/21

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
PRIMECAP Odyssey Aggressive Growth Fund 7,066,700 9.54 18,800 3/31/21
Federated Hermes Kaufmann Small Cap Fund 3,960,000 5.35 -- 12/31/20
Federated Hermes Kaufmann Fund 3,385,000 4.57 -- 12/31/20
Vanguard US Opportunities Fund 3,267,000 4.41 81,400 3/31/21
Vanguard Total Stock Market Index Fund 2,126,813 2.87 -- 4/30/21
iShares Russell 2000 ETF 1,577,655 2.13 -11,835 5/31/21
Vanguard Extended Market Index Fund 926,583 1.25 -- 4/30/21
iShares NASDAQ Biotechnology ETF 602,975 0.81 3,164 5/31/21
iShares Russell 2000 Growth ETF 577,525 0.78 -6,543 5/31/21
Fidelity Small Cap Index Fund 427,152 0.58 65,182 1/31/21

* Insider values reflect direct beneficial ownership.

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