Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
PRIMECAP Management Company 10,061,500 14.26 -6,300 9/30/20
Federated Hermes Global Investment Management Corp. 7,453,011 10.56 14,657 9/30/20
BVF Partners L.P. 4,585,638 6.50 -2,505,000 9/30/20
BlackRock Institutional Trust Company, N.A. 4,302,184 6.10 -7,776 9/30/20
Point72 Asset Management, L.P. 3,727,506 5.28 -373,933 9/30/20
The Vanguard Group, Inc. 3,555,945 5.04 287,054 9/30/20
Great Point Partners, LLC 2,918,581 4.14 656,881 9/30/20
Delphi Ventures L.P. 2,426,702 3.44 -- 3/31/20
Wellington Management Company, LLP 2,113,772 3.00 1,543,009 9/30/20
Advanced Technology Ventures 2,110,082 2.99 -- 3/31/20

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
PRIMECAP Odyssey Aggressive Growth Fund 7,047,900 9.99 117,300 9/30/20
Federated Hermes Kaufmann Small Cap Fund 3,960,000 5.61 -- 9/30/20
Federated Hermes Kaufmann Fund 3,385,000 4.80 -- 9/30/20
Vanguard US Opportunities Fund 3,013,600 4.27 -123,600 9/30/20
Vanguard Total Stock Market Index Fund 2,130,062 3.02 -201,950 11/30/20
iShares Russell 2000 ETF 1,566,083 2.22 80,215 12/31/20
Vanguard Extended Market Index Fund 857,649 1.22 5,402 11/30/20
iShares NASDAQ Biotechnology ETF 610,659 0.87 610,659 12/31/20
iShares Russell 2000 Growth ETF 597,881 0.85 -5,089 12/31/20
MEDICAL BioHealth 455,179 0.65 -- 11/30/20

* Insider values reflect direct beneficial ownership.

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