Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
BVF Partners L.P. 6,750,482 12.55 3,727,000 6/30/19
Federated Global Investment Management Corp. 5,485,063 10.20 1,270,000 6/30/19
Wellington Management Company, LLP 3,542,670 6.59 -107,227 6/30/19
BlackRock Institutional Trust Company, N.A. 2,438,260 4.53 69,999 6/30/19
Delphi Ventures L.P. 2,426,702 4.51 -- 3/31/19
The Vanguard Group, Inc. 2,113,189 3.93 515,969 6/30/19
Advanced Technology Ventures 2,110,082 3.92 -- 3/31/19
Point72 Asset Management, L.P. 1,935,800 3.60 1,935,800 6/30/19
Dimensional Fund Advisors, L.P. 1,465,171 2.72 46,770 6/30/19
Adage Capital Management, L.P. 1,200,000 2.23 500,000 6/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Federated Kaufmann Fund 2,351,482 4.37 -- 3/31/19
Vanguard Total Stock Market Index Fund 1,409,585 2.62 -- 8/31/19
Federated Kaufmann Small Cap Fund 1,352,700 2.52 219,228 3/31/19
iShares Russell 2000 ETF 684,851 1.27 -34,190 8/31/19
Vanguard Extended Market Index Fund 660,428 1.23 7,185 8/31/19
DFA U.S. Small Cap Portfolio 354,407 0.66 84,080 4/30/19
DFA U.S. Targeted Value Portfolio 349,946 0.65 6,700 4/30/19
Wellington Global Healthcare Equity Fund 299,348 0.56 27,348 6/30/19
TIAA-CREF Quant Small-Cap Equity Fund 274,027 0.51 -- 7/31/19
iShares Russell 2000 Value ETF 271,915 0.51 2,184 8/31/19

* Insider values reflect direct beneficial ownership.

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