Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
BVF Partners L.P. 6,750,482 13.09 3,727,000 6/25/19
Federated Global Investment Management Corp. 4,215,063 8.17 447,300 4/30/19
Wellington Management Company, LLP 3,649,897 7.08 -58,761 3/31/19
Delphi Ventures L.P. 2,426,702 4.70 -- 3/31/19
BlackRock Institutional Trust Company, N.A. 2,368,261 4.59 -22,218 3/31/19
Advanced Technology Ventures 2,110,082 4.09 -- 3/31/19
The Vanguard Group, Inc. 1,597,220 3.10 135,957 3/31/19
Dimensional Fund Advisors, L.P. 1,418,401 2.75 174,355 3/31/19
Adage Capital Management, L.P. 700,000 1.36 -- 3/31/19
State Street Global Advisors (US) 542,648 1.05 8,122 3/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Federated Kaufmann Fund 2,351,482 4.56 -- 3/31/19
Federated Kaufmann Small Cap Fund 1,352,700 2.62 219,228 3/31/19
Vanguard Total Stock Market Index Fund 1,283,657 2.49 393,400 6/30/19
iShares Russell 2000 ETF 695,901 1.35 7,670 6/30/19
Vanguard Extended Market Index Fund 635,843 1.23 113,774 6/30/19
DFA U.S. Small Cap Portfolio 354,407 0.69 84,080 4/30/19
DFA U.S. Targeted Value Portfolio 349,946 0.68 6,700 4/30/19
TIAA-CREF Quant Small-Cap Equity Fund 274,027 0.53 -4,400 5/31/19
Wellington Global Healthcare Equity Fund 272,000 0.53 272,000 12/31/17
iShares Russell 2000 Value ETF 269,367 0.52 -14,971 6/30/19

* Insider values reflect direct beneficial ownership.

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