Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 4,524,551 12.75 -153,669 12/31/17
BlackRock Institutional Trust Company, N.A. 2,457,540 6.93 638,511 12/31/17
Delphi Ventures L.P. 2,426,702 6.84 -- 3/31/17
Morgenthaler Ventures 2,161,915 6.09 -- 9/30/16
Advanced Technology Ventures 2,110,082 5.95 -- 3/31/17
Incyte Corporation 1,720,430 4.85 1,720,430 1/30/17
Viking Global Investors LP 1,643,681 4.63 -980,852 12/31/17
Adage Capital Management, L.P. 1,500,000 4.23 -1,947,873 12/31/17
Millennium Management LLC 1,439,573 4.06 957,437 12/31/17
The Vanguard Group, Inc. 1,112,175 3.13 12,244 12/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 622,754 1.76 29,100 1/31/18
iShares Russell 2000 ETF 602,109 1.70 -14,652 1/31/18
Fidelity Select Biotechnology Portfolio 528,522 1.49 -74,800 12/31/17
iShares NASDAQ Biotechnology ETF 479,489 1.35 1,714 1/31/18
Franklin Templeton Invest-Biotechnology Discovery 440,000 1.24 -34,500 12/31/17
Vanguard Extended Market Index Fund 334,749 0.94 -1,509 1/31/18
American Century Small Company Fund 334,329 0.94 107,509 12/31/17
Hartford Healthcare Fund 284,888 0.80 -11,132 12/31/17
Franklin Biotechnology Discovery Fund 275,500 0.78 -- 12/31/17
Hartford SmallCap Growth HLS Fund 254,125 0.72 -- 12/31/17

* Insider values reflect direct beneficial ownership.

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