Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 4,892,594 13.60 -93,870 6/30/18
BlackRock Institutional Trust Company, N.A. 2,745,476 7.63 122,244 6/30/18
Delphi Ventures L.P. 2,426,702 6.74 -- 3/31/18
Advanced Technology Ventures 2,110,082 5.86 -- 3/31/18
BVF Partners L.P. 2,019,000 5.61 2,019,000 9/4/18
Federated Global Investment Management Corp. 1,888,900 5.25 466,700 6/30/18
Incyte Corporation 1,720,430 4.78 1,720,430 1/30/17
The Vanguard Group, Inc. 1,225,712 3.41 48,296 6/30/18
Numeric Investors LLC 835,792 2.32 -98,890 6/30/18
Dimensional Fund Advisors, L.P. 792,300 2.20 319,906 6/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Federated Kaufmann Fund 1,340,500 3.72 340,500 6/30/18
iShares Russell 2000 ETF 713,913 1.98 -11,303 8/31/18
Vanguard Total Stock Market Index Fund 703,130 1.95 -- 8/31/18
Federated Kaufmann Small Cap Fund 513,100 1.43 117,500 6/30/18
iShares NASDAQ Biotechnology ETF 421,887 1.17 1,300 8/31/18
Vanguard Extended Market Index Fund 391,453 1.09 19,431 8/31/18
American Century Small Company Fund 299,684 0.83 -135,293 6/30/18
iShares Russell 2000 Value ETF 295,878 0.82 -6,685 8/31/18
TIAA-CREF Small Cap Equity Fund 284,227 0.79 -- 7/31/18
Wellington Global Healthcare Equity Fund 272,000 0.76 272,000 12/31/17

* Insider values reflect direct beneficial ownership.

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