Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 4,017,468 10.54 -875,126 9/30/18
BlackRock Institutional Trust Company, N.A. 2,738,942 7.18 -6,534 9/30/18
BVF Partners L.P. 2,544,000 6.67 2,544,000 9/30/18
Delphi Ventures L.P. 2,426,702 6.37 -- 3/31/18
Advanced Technology Ventures 2,110,082 5.53 -- 3/31/18
Federated Global Investment Management Corp. 1,888,900 4.95 -- 9/30/18
Incyte Corporation 1,720,430 4.51 1,720,430 1/30/17
The Vanguard Group, Inc. 1,291,646 3.39 65,934 9/30/18
Dimensional Fund Advisors, L.P. 987,824 2.59 195,524 9/30/18
Numeric Investors LLC 748,882 1.96 -86,910 9/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Federated Kaufmann Fund 1,340,500 3.52 -- 9/30/18
iShares Russell 2000 ETF 754,807 1.98 3,683 10/31/18
Vanguard Total Stock Market Index Fund 709,287 1.86 6,157 9/30/18
Federated Kaufmann Small Cap Fund 513,100 1.35 -- 9/30/18
Vanguard Extended Market Index Fund 434,506 1.14 62,484 9/30/18
iShares NASDAQ Biotechnology ETF 407,847 1.07 -2,600 10/31/18
iShares Russell 2000 Value ETF 293,968 0.77 2,674 10/31/18
TIAA-CREF Small Cap Equity Fund 284,227 0.75 -- 9/30/18
Wellington Global Healthcare Equity Fund 272,000 0.71 272,000 12/31/17
DFA U.S. Small Cap Portfolio 270,158 0.71 141,774 7/31/18

* Insider values reflect direct beneficial ownership.

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