Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 4,986,464 13.91 461,913 3/31/18
BlackRock Institutional Trust Company, N.A. 2,623,232 7.32 165,692 3/31/18
Delphi Ventures L.P. 2,426,702 6.77 -- 3/31/18
Advanced Technology Ventures 2,110,082 5.89 -- 3/31/18
Incyte Corporation 1,720,430 4.80 1,720,430 1/30/17
Federated Global Investment Management Corp. 1,422,200 3.97 1,422,200 3/31/18
The Vanguard Group, Inc. 1,177,416 3.28 65,241 3/31/18
Numeric Investors LLC 934,682 2.61 273,918 3/31/18
American Century Investment Management, Inc. 796,726 2.22 193,607 3/31/18
Millennium Management LLC 713,131 1.99 -726,442 3/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 703,130 1.96 60,425 5/31/18
iShares Russell 2000 ETF 641,181 1.79 29,859 5/31/18
Fidelity Select Biotechnology Portfolio 489,722 1.37 -38,800 4/30/18
iShares NASDAQ Biotechnology ETF 419,807 1.17 -20,280 5/31/18
Vanguard Extended Market Index Fund 354,686 0.99 5,720 5/31/18
American Century Small Company Fund 334,329 0.93 107,509 12/31/17
Hartford SmallCap Growth HLS Fund 275,262 0.77 21,137 4/30/18
Wellington Global Healthcare Equity Fund 272,000 0.76 272,000 12/31/17
iShares Russell 2000 Growth ETF 270,707 0.76 16,104 5/31/18
Hartford Healthcare Fund 263,659 0.74 -3,168 4/30/18

* Insider values reflect direct beneficial ownership.

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