Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 4,524,551 12.62 -153,669 12/31/17
BlackRock Institutional Trust Company, N.A. 2,457,540 6.86 638,511 12/31/17
Delphi Ventures L.P. 2,426,702 6.77 -- 3/31/17
Advanced Technology Ventures 2,110,082 5.89 -- 3/31/17
Incyte Corporation 1,720,430 4.80 1,720,430 1/30/17
Viking Global Investors LP 1,643,681 4.59 -980,852 12/31/17
Adage Capital Management, L.P. 1,500,000 4.18 -1,947,873 12/31/17
Millennium Management LLC 1,439,573 4.02 957,437 12/31/17
The Vanguard Group, Inc. 1,112,175 3.10 12,244 12/31/17
Citadel LLC 879,927 2.45 399,254 12/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 622,754 1.74 29,100 2/28/18
iShares Russell 2000 ETF 611,322 1.71 -5,439 3/31/18
Fidelity Select Biotechnology Portfolio 528,522 1.47 -- 2/28/18
iShares NASDAQ Biotechnology ETF 440,087 1.23 -37,688 3/31/18
Franklin Templeton Invest-Biotechnology Discovery 394,195 1.10 -45,805 3/31/18
Vanguard Extended Market Index Fund 335,029 0.93 -1,229 2/28/18
American Century Small Company Fund 334,329 0.93 107,509 12/31/17
Franklin Biotechnology Discovery Fund 275,500 0.77 -- 12/31/17
Hartford Healthcare Fund 269,925 0.75 -14,963 2/28/18
iShares Russell 2000 Growth ETF 254,603 0.71 -3,432 3/31/18

* Insider values reflect direct beneficial ownership.

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