Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 4,017,468 10.54 -875,126 9/30/18
BlackRock Institutional Trust Company, N.A. 2,738,942 7.18 -6,534 9/30/18
BVF Partners L.P. 2,544,000 6.67 2,544,000 9/30/18
Delphi Ventures L.P. 2,426,702 6.37 -- 3/31/18
Advanced Technology Ventures 2,110,082 5.53 -- 3/31/18
Federated Global Investment Management Corp. 1,888,900 4.95 -- 9/30/18
The Vanguard Group, Inc. 1,291,646 3.39 65,934 9/30/18
Dimensional Fund Advisors, L.P. 987,824 2.59 195,524 9/30/18
Numeric Investors LLC 748,882 1.96 -86,910 9/30/18
Adage Capital Management, L.P. 700,000 1.84 -- 9/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Federated Kaufmann Fund 1,340,500 3.52 -- 9/30/18
iShares Russell 2000 ETF 756,331 1.98 5,207 12/31/18
Vanguard Total Stock Market Index Fund 747,787 1.96 38,500 11/30/18
Vanguard Extended Market Index Fund 514,897 1.35 80,391 11/30/18
Federated Kaufmann Small Cap Fund 513,100 1.35 -- 9/30/18
iShares Russell 2000 Value ETF 308,293 0.81 16,999 12/31/18
TIAA-CREF Quant Small-Cap Equity Fund 284,227 0.75 -- 11/30/18
Wellington Global Healthcare Equity Fund 272,000 0.71 272,000 12/31/17
DFA U.S. Small Cap Portfolio 270,158 0.71 141,774 7/31/18
Hartford Healthcare Fund 258,913 0.68 -- 11/30/18

* Insider values reflect direct beneficial ownership.

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