Media & Investors

Ownership Summary

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 3,708,658 9.55 -308,810 12/31/18
Federated Global Investment Management Corp. 3,548,535 9.14 1,659,635 12/31/18
BVF Partners L.P. 3,298,282 8.49 754,282 12/31/18
Delphi Ventures L.P. 2,426,702 6.25 -- 3/31/18
BlackRock Institutional Trust Company, N.A. 2,390,479 6.16 -348,463 12/31/18
Advanced Technology Ventures 2,110,082 5.43 -- 3/31/18
The Vanguard Group, Inc. 1,461,263 3.76 169,617 12/31/18
Dimensional Fund Advisors, L.P. 1,244,046 3.20 256,222 12/31/18
Adage Capital Management, L.P. 700,000 1.80 -- 12/31/18
State Street Global Advisors (US) 534,526 1.38 -18,253 12/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Federated Kaufmann Fund 1,340,500 3.45 -- 9/30/18
Vanguard Total Stock Market Index Fund 889,885 2.29 140,798 2/28/19
iShares Russell 2000 ETF 708,325 1.82 -48,006 2/28/19
Vanguard Extended Market Index Fund 577,216 1.49 15,621 2/28/19
Federated Kaufmann Small Cap Fund 513,100 1.32 -- 9/30/18
DFA U.S. Targeted Value Portfolio 341,134 0.88 169,493 10/31/18
iShares Russell 2000 Value ETF 291,676 0.75 -16,617 2/28/19
TIAA-CREF Quant Small-Cap Equity Fund 284,227 0.73 -- 1/31/19
Wellington Global Healthcare Equity Fund 272,000 0.70 272,000 12/31/17
DFA U.S. Small Cap Portfolio 244,958 0.63 -25,200 10/31/18

* Insider values reflect direct beneficial ownership.

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